interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development
EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
Clinical Trials Information System (CTIS).
The EU Clinical Trials Register currently displays
43881
clinical trials with a EudraCT protocol, of which
7295
are clinical trials conducted with subjects less than 18 years old.
The register also displays information on
18700
older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).
Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see
Frequently Asked Questions ).
Sponsor Name:dept of endocrinology J 106, herlev Hosptial
Full Title: Quality of life related to recombinant TSH treatment compared to
no treatment related to iodine uptake, in patient with thyroid cancer.
A double blinded, randomized crossover study.
Dathyrca I
Medical condition: in patients with thyroid cancer (follicular or papillary), injektion with recombinant TSH to increase s-TSH before iodine uptake to detect remaining cancer og recurrence of cancer in patients surg...
Full Title: An Open-Label, Multi-Center Phase II Study of the BRAF Inhibitor RO5185426 in Patients with Metastatic or Unresectable Papillary Thyroid Cancer (PTC) positive for the BRAF V600 Mutation and Resista...
Medical condition: Metastatic or unresectable papillary thyroid cancer positive for BRAFV600 mutation and resistant to radioactive iodine therapy
Sponsor Name:Universitätsklinikum Schleswig-Holstein
Full Title: Phase 2 trial of pemetrexed (Alimta™) combined with paclitaxel in patients with recurrent/advanced follicular, papillary or anaplastic thyroid cancer
Medical condition: recurrent/advanced follicular, papillary or anaplastic thyroid cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10016935
Follicular thyroid cancer
LLT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10002240
Anaplastic thyroid cancer
LLT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Sponsor Name:European Organisation for Research and Treatment of Cancer (EORTC)
Full Title: A phase II study exploring the safety and efficacy of nintedanib (BIBF1120) as second line therapy for patients with either differentiated or medullary thyroid cancer progressing after first line t...
Medical condition: Histologically confirmed differentiated or medullary thyroid cancer by local pathologist.
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10027105
Medullary thyroid cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10066474
Thyroid cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A Randomised, Double-Blind, Placebo-Controlled, Multi-Centre Phase III Study to Assess the Efficacy and Safety of Vandetanib (CAPRELSA™) 300 mg in Patients with Papillary or Poorly Differentiated T...
Medical condition: Papillary Differentiated Thyroid Cancer, Poorly Differentiated Thyroid Cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10071029
Thyroid cancer stage III
PT
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10071030
Thyroid cancer stage IV
PT
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10072162
Thyroid cancer recurrent
PT
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10066474
Thyroid cancer
PT
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10055107
Thyroid cancer metastatic
PT
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Sponsor Name:Spanish Group of Neuroendocrine Tumors (GETNE)
Full Title: A phase II study of durvalumab (MEDI4736) plus tremelimumab for the treatment of patients with
progressive, refractory advanced thyroid carcinoma - The DUTHY trial
Medical condition: Advanced, radioiodine-refractory differentiated thyroid carcinoma, including papillary,
follicular, Hürtle Cell and poorly-differentiated thyroid carcinoma (DTC).
Advanced medullary thyroid carcino...
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10076603
Poorly differentiated thyroid carcinoma
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10002240
Anaplastic thyroid cancer
PT
20.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10016935
Follicular thyroid cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10027105
Medullary thyroid cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10033701
Papillary thyroid cancer
PT
20.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10071027
Thyroid cancer stage I
PT
20.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: An open-label, multi-center, roll-over study to assess long term safety of lenvatinib monotherapy or lenvatinib combination regimen or comparator treatment arm to cancer patients in Eisai sponsored...
Medical condition: solid tumors or lymphomas, as defined in parent protocol
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10055107
Thyroid cancer metastatic
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10016935
Follicular thyroid cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10027105
Medullary thyroid cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10066474
Thyroid cancer
PT
24.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10033701
Papillary thyroid cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A Randomized, Double Blind, placebo-controlled Phase II, Multi-Centre Study to Assess the Efficacy and Safety of Zactima™ in Patients with advanced or metastatic papillary or follicular Thyroid Car...
Medical condition: Advanced or metastatic papillary or follicular Thyroid Carcinoma
Sponsor Name:Sheffield Teaching Hospitals NHS Foundation Trust
Full Title: Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy.
Medical condition: Iodine-refractory thyroid cancer of papillary, follicular, Hürthle cell or poorly differentiated carcinoma
Disease:
Version
SOC Term
Classification Code
Term
Level
18.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10071029
Thyroid cancer stage III
PT
18.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10016935
Follicular thyroid cancer
PT
18.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10071030
Thyroid cancer stage IV
PT
18.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10066474
Thyroid cancer
PT
18.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10055107
Thyroid cancer metastatic
PT
18.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: Efficacy of a selective MEK (trametinib) and BRAFV600E (dabrafenib) inhibitors associated with radioactive iodine (RAI) for the treatment of refractory metastatic differentiated thyroid cancer with...
Medical condition: Metastatic Radioactive Iodine Refractory Thyroid Cancer Patients with RAS or BRAF mutation
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10016935
Follicular thyroid cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10066474
Thyroid cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: Phase II, Multicenter, Open-label, Single Arm Trial to Evaluate the Safety and Efficacy of Oral E7080 in Medullary and Iodine-131 Refractory, Unresectable Differentiated Thyroid Cancers, Stratified...
Medical condition: Medullary thyroid cancer [MTC] or radioiodine (131*I) refractory/resistant differentiated thyroid cancer[DTC]:
Determine the pharmacokinetic (PK) profile and the pharmacokinetic/pharmacodynamic (PK...
Full Title: A RANDOMIZED, COMPARATIVE,CONTROLLED PHASE III, MULTICENTER STUDY OF HEXVIX FLUORESCENCE CYSTOSCOPY ANDWHITE LIGHT CYSTOSCOPY IN THE DETECTION OF PAPILLARY BLADDER CANCER AND THE EARLYRECURRENCE RA...
Full Title: A Phase 1/2 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CM24 in combination with nivolumab in adults with advanced solid tumours
Medical condition: Part A- Recurrent and metastatic non-small cell lung cancer (NSCLC), pancreatic cancer, ovarian cancer, papillary thyroid cancer, colorectal adenocarcinoma and melanoma
Part B- Recurrent or metasta...
Disease:
Version
SOC Term
Classification Code
Term
Level
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10033604
Pancreatic cancer
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10033128
Ovarian cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061873
Non-small cell lung cancer
PT
24.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10033701
Papillary thyroid cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10025650
Malignant melanoma
PT
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: Intravesical instillation of BCG strain RIVM versus TICE for prevention of recurrenec in patients with high-risk papillary superficial carcinomas of the urinary bladder. A randomised phase II clini...
Medical condition: immunostimulating adjuvant therapy of superficial carcinomas of the urinary bladder
Full Title: A phase III, single-arm study to evaluate the efficacy and safety of ONCOFID-P-B (paclitaxel-hyaluronic acid conjugate) administered intravesically to patients with BCG-unresponsive Carcinoma in Si...
Medical condition: BCG-unresponsive Carcinoma in Situ of the bladder with or without Ta-T1 papillary disease
Full Title: A Double-Blind, Randomized Phase III Study Evaluating the Efficacy and Safety of Sorafenib Compared to Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid Cancer
Medical condition: Differentiated thyroid cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10066136
Huerthle cell carcinoma
PT
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10016935
Follicular thyroid cancer
PT
19.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A Phase II Study of Sodium Cridanimod in Conjunction with Progestin Therapy in Patients with Progesterone Receptor Negative Recurrent or Persistent Endometrial Carcinoma.
Medical condition: PrR negative papillary serous adenocarcinoma, endometroid type of endometrial carcinoma
Disease:
Version
SOC Term
Classification Code
Term
Level
17.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10014743
Endometrial carcinoma
LLT
17.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10014747
Endometrial carcinoma recurrent
LLT
17.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A single arm, multicenter phase II trial of RAD001 as monotherapy in the treatment of advanced papillary renal cell cancer
Medical condition: Patients who have metastatic papillary cancer of the kidney and have not received prior systemic treatment for their metastatic RCC. This multicenter international trial will enroll a maximum of 60...
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